* { box-sizing: border-box; }
html { scroll-padding-block-start: 2rem; }
body { margin: 0; min-width: 0; }
svg { display: block; max-width: 100%; }
button, a { -webkit-tap-highlight-color: transparent; }
button { cursor: pointer; }
a { min-height: 44px; }
main { outline: none; }
.page-shell { position: relative; max-width: 1280px; width: calc(100% - 6rem); margin-inline: auto; }
.guide-masthead { display: flex; justify-content: space-between; align-items: center; gap: 2rem; padding-block: 2rem; }
.guide-name { display: flex; align-items: center; gap: 1rem; }
.guide-name .atomic-mark { width: 44px; height: 44px; }
.name-second-line { display: block; }
.breadcrumb ol { display: flex; flex-wrap: wrap; align-items: center; gap: 0.5rem; margin: 0; padding: 0; list-style: none; }
.breadcrumb li { display: flex; align-items: center; gap: 0.75rem; min-height: 44px; }
.breadcrumb a { display: inline-flex; align-items: center; padding-inline: 0.5rem; }
.opening { display: grid; grid-template-columns: minmax(0, 7fr) minmax(0, 5fr); gap: 4rem; align-items: center; padding-block: clamp(4rem, 7vw, 6rem); }
.opening-copy > :first-child { margin-top: 0; }
.opening-lead { margin-block: 2rem; }
.opening-copy .next-link { margin-top: 0.5rem; }
.starting-question { position: relative; isolation: isolate; margin: 2rem 0 2rem 1rem; padding: 3rem 2.5rem; }
.starting-question .atomic-mark { position: absolute; width: 72px; height: 72px; top: -2.75rem; right: -0.5rem; }
.starting-question h2 { position: relative; }
.starting-question p { position: relative; }
.question-curve { position: absolute; width: 92px; height: 36px; bottom: -1.5rem; left: -1.5rem; z-index: -1; }
.peptide-meaning { display: grid; grid-template-columns: minmax(0, 4fr) minmax(0, 8fr); column-gap: 4rem; padding-block: 2rem; }
.peptide-meaning .eyebrow { grid-column: 1; }
.peptide-meaning h2 { grid-column: 1; grid-row: 2 / span 4; }
.peptide-meaning > p:not(.eyebrow) { grid-column: 2; margin-top: 0; }
.peptide-meaning > p:not(.eyebrow):nth-of-type(2) { grid-row: 1; }
.medicine-overview, .boise-care, .next-conversation, .visit-questions, .payment-questions, .reading-list, .reading-date { margin-top: clamp(4rem, 8vw, 8rem); }
.section-heading { margin-bottom: 2rem; }
.medicine-paths { display: grid; grid-template-columns: repeat(12, minmax(0, 1fr)); gap: 2rem; align-items: start; }
.approved-medicine, .made-to-order, .research-label { padding: 2rem; position: relative; }
.approved-medicine { grid-column: 1 / span 7; }
.made-to-order { grid-column: 8 / span 5; grid-row: 1 / span 2; padding-block: 2.5rem 3.5rem; }
.research-label { grid-column: 1 / span 7; }
.takeaway { padding-top: 1rem; margin-top: 1.5rem; }
.boise-care { display: grid; grid-template-columns: minmax(0, 4fr) minmax(0, 8fr); gap: 4rem; }
.boise-heading { position: relative; }
.boise-heading .atomic-mark { width: 80px; height: 80px; margin-top: 3rem; }
.boise-copy p:first-child { margin-top: 0; }
.next-conversation { display: flex; justify-content: space-between; align-items: center; gap: 2rem; padding-block: 2rem; }
.next-conversation > div { max-width: 64ch; }
.next-conversation .next-link { flex-shrink: 0; max-width: 24rem; }
.reading-link, .next-link, .return-link { display: inline-flex; justify-content: space-between; align-items: center; gap: 1rem; min-height: 48px; max-width: 100%; padding-block: 0.75rem; }
.next-link { padding: 1rem 1.5rem; }
.reading-arrow { width: 24px; height: 24px; flex: 0 0 24px; }
.guide-footer { display: flex; justify-content: space-between; align-items: center; gap: 2rem; padding-block: 3rem; margin-top: clamp(4rem, 8vw, 8rem); }
.footer-note { display: flex; align-items: center; gap: 1.5rem; max-width: 66ch; }
.footer-note p { margin: 0; }
.footer-mark { flex-shrink: 0; }
.return-link { flex-shrink: 0; }
.skip-link { position: absolute; top: 0; left: 1.5rem; transform: translateY(-110%); z-index: 3; display: flex; align-items: center; padding: 0.75rem 1rem; }
.skip-link:focus { transform: none; }
.visit-note, .record-note { position: relative; padding: 2.5rem; margin-left: 1rem; }
.note-lines { display: block; width: 100%; height: 72px; margin-top: 1.5rem; }
.visit-questions { display: grid; grid-template-columns: repeat(12, minmax(0, 1fr)); gap: 2rem; }
.visit-questions > article { padding: 2rem; }
.clinician-question { grid-column: 1 / span 5; }
.assessment-question { grid-column: 6 / span 7; }
.medicine-question { grid-column: 1 / span 7; }
.compound-question { grid-column: 8 / span 5; }
.payment-questions { display: grid; grid-template-columns: minmax(0, 4fr) minmax(0, 8fr); gap: 4rem; padding: 3rem; }
.payment-heading .atomic-mark { width: 80px; height: 80px; margin-top: 3rem; }
.payment-copy > p:first-child { margin-top: 0; }
.price-fact { padding-block: 1.5rem; }
.bill-questions { margin-top: 2rem; padding-top: 1.5rem; }
.record-note .atomic-mark { width: 64px; height: 64px; margin-bottom: 2rem; }
.reading-list { scroll-margin-top: 2rem; }
.reading-list > article { padding-block: 2rem; display: grid; grid-template-columns: minmax(0, 5fr) minmax(0, 7fr); column-gap: 4rem; }
.record-heading { grid-column: 1; grid-row: 1 / span 8; display: flex; align-items: flex-start; gap: 1rem; }
.reading-list article > p, .reading-list .source-links { grid-column: 2; }
.reading-list article > p:first-of-type { margin-top: 0; }
.source-links { display: flex; flex-direction: column; align-items: stretch; gap: 0.5rem; margin-block: 1rem; }
.source-links .reading-link { width: 100%; padding-inline: 1rem; }
.reading-date { max-width: 72ch; padding-block: 1rem; }
.missing-page { padding-block: 6rem; min-height: 55vh; }
.evidence-drawer { position: fixed; inset: 0 0 0 auto; margin: 0; width: min(760px, 100%); height: 100dvh; max-height: none; max-width: 100%; padding: 2rem; overflow-y: auto; overscroll-behavior: contain; }
.drawer-bar { display: flex; justify-content: flex-end; position: sticky; top: -2rem; padding-block: 1rem; z-index: 1; }
.drawer-close { padding: 0.75rem 1rem; min-height: 48px; }
.evidence-drawer .reading-list { margin-top: 1.5rem; }
.evidence-drawer .reading-list > article { grid-template-columns: minmax(0, 1fr); }
.evidence-drawer .record-heading { grid-column: 1; grid-row: auto; margin-bottom: 1.5rem; }
.evidence-drawer article > p, .evidence-drawer .source-links { grid-column: 1; }
body:has(.evidence-drawer[open]) { overflow: hidden; }
@media (max-width: 900px) {
  .page-shell { width: calc(100% - 3rem); }
  .opening { gap: 2rem; }
  .starting-question, .visit-note, .record-note { margin-left: 0; padding: 2rem; }
  .boise-care, .peptide-meaning, .payment-questions, .reading-list > article { column-gap: 2rem; }
  .payment-questions { padding: 2rem; }
  .next-conversation { flex-direction: column; align-items: flex-start; }
  .guide-footer { align-items: flex-start; }
}
@media (max-width: 640px) {
  .page-shell { width: calc(100% - 2.5rem); }
  .guide-masthead { align-items: flex-start; flex-direction: column; gap: 1rem; padding-block: 1.5rem; }
  .guide-name .atomic-mark { width: 36px; height: 36px; }
  .breadcrumb ol { gap: 0; }
  .breadcrumb a { padding-left: 0; padding-right: 0.75rem; }
  .opening { grid-template-columns: minmax(0, 1fr); padding-block: 3rem 1rem; gap: 3rem; }
  .opening-lead { margin-block: 1.5rem; }
  .starting-question { margin: 1rem 0; padding: 2.5rem 1.75rem; }
  .starting-question .atomic-mark { width: 56px; height: 56px; top: -1.5rem; right: 1rem; }
  .question-curve { left: 1rem; }
  .peptide-meaning, .boise-care, .payment-questions { display: block; }
  .peptide-meaning { padding-block: 1rem; }
  .peptide-meaning > p:not(.eyebrow) { margin-block: 1rem; }
  .medicine-paths, .visit-questions { grid-template-columns: minmax(0, 1fr); }
  .medicine-paths > article, .visit-questions > article { grid-column: 1; grid-row: auto; padding: 1.75rem; }
  .boise-heading .atomic-mark { display: none; }
  .boise-copy { margin-top: 1.5rem; }
  .payment-questions { padding: 1.75rem; }
  .payment-heading .atomic-mark { width: 48px; height: 48px; margin-top: 1.5rem; }
  .payment-copy { margin-top: 2rem; }
  .visit-note, .record-note { padding: 1.75rem; }
  .reading-list > article { grid-template-columns: minmax(0, 1fr); }
  .record-heading { grid-column: 1; grid-row: auto; margin-bottom: 1.5rem; }
  .reading-list article > p, .reading-list .source-links { grid-column: 1; }
  .guide-footer { flex-direction: column; gap: 1rem; padding-block: 2rem; }
  .footer-note { align-items: flex-start; gap: 1rem; }
  .next-link { width: 100%; }
  .evidence-drawer { padding: 1.25rem; }
  .drawer-bar { top: -1.25rem; }
}